Meilleure réponse: i just googled advil and it told me the active ingredient is ibuprofen so you'd have to wait 6 hours before taking an aspirin. you can take paracetamol tablets or you can buy a gel or a spray to relieve the pain locally in the meantime. How Soon Can You Take Aspirin After Ibuprofen. How soon can I take ibuprofen after aspirin. Well if you are really sore you can take 3 ibuprofen 3x a day. Aspirin and ibuprofen can cause stomach bleeding, especially if you take too much. That means taking them together increases your risk. The risk of stomach bleeding from these drugs continues to. You take both ibuprofen and aspirin. You need to know that taking ibuprofen can reduce the heart-protective effect of aspirin. The reason is that ibuprofen latches on to platelets in the blood at the same spots where aspirin attaches to platelets, thereby decreasing the anti-clotting effects of aspirin. According to my doctor, 4 hours. You can switch them up. Take acetaminophen, (Tylenol), then wait 4 hours and take Ibuprofen, wait another 4 hours and take acetaminophen and so on. If you use ibuprofen occasionally, there is only a minimal risk that the ibuprofen will interfere with the effect of low-dose aspirin. If you need only a single dose of ibuprofen, take it 8 hours before or 30 minutes after taking a regular (not enteric-coated) low-dose aspirin. You should always avoid taking aspirin and Motrin together. This mix can potentially cause severe abdominal issues. Taking hydrocodone and Motrin together is fine. As well a This mix can. Avoid taking Motrin if you are taking aspirin to prevent stroke or heart attack. Ibuprofen can make aspirin less effective in protecting your heart and blood vessels. If you must use both medications, take the Motrin at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form). Taking ibuprofen in addition to aspirin can, in fact, reduce the positive effects of aspirin, says Dr. Christopher Calapai, DO, an osteopathic physician board certified in family medicine.